When we take some medicines some nutrients are depleted during the metabolism of drugs.Eg-Folic acid is depleted during the metabolism of Methotrexate.Lets discuss few drugs and the affected nutrients

Drug classification :Analgesics

Drugs:Aspirin,salicylates

Affected nutrients:Vitamin C,folic acid,glycine,histidine,potassium.zinc,vitamin K

Mechanism:

Drug tend to produce Vit C deficiency in normal individuals.Chronic use may cause iron depletion due to GI bleeding.Aspirin depletes Folic acid by displacing bound serum folate.Also causes potassium loss through urine.Aspirin overdose depletes plasma glycine.

Salicylates on high dose causes Vitamin K deficiency.

Reference

Laboratory Evaluation for Integrative and Functional Medicine by Richard S Lord.